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KMID : 0358419960390050897
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Korean Journal of Obstetrics and Gynecology
1996 Volume.39 No. 5 p.897 ~ p.905
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Change of Serum Lipid Peroxides after Low-dose Aspirin Therapy in Patients with Unknown Recurrent Spontaneous Abortion
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박문일
나도수/유중배/정성노/이재억/황윤영
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Abstract
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Lipid peroxides(LPO) are toxic compounds that damage cells and inhibit prostacyclin synthase. It is responsible for endothelial cell damage and decreased prostacyclin(PC) levels. Preeclampsia is associated with an imbalance of increased
thromboxane(TX)
and decreased prostacylin. Low-dose aspirin therapy reduces the incidence of preeclampsia, presumbly by selective inhibition of TX and LPO, however, there were limited studies in the field of recurrent abortion., This study was done to invesgate
the
effect of low-dose aspirin on serum LPO levels in patients of unknown recurrent abortion. The followings are summarized results.
1. Of 14 patients of recurrent abortion who were receiving low-dose aspirin(100mg/day) therapy between 5-12th gestational weeks, 38 tests of LPO were done with TBA method.
2. There were no significant differences of mean serum LPO levels as increasing gestational weeks(21 serial tests in 7 patients).
3. As increasing gestational weeks in each patient, six patients among 7 patients(85.7%) revealed decreasing trends of serum LPO levels during low-dose aspirin therapy. The serum LPO levels were decreased after 48 hours of low-dose aspirin
therapy
in 4
cases among 10paired-test.
For these results, we could confirm the low-dose aspirin therapy inhibit serum LPO levels during the frist trimester in patients of recurrent abortion. And it is supposed that at least 1 week interval is needed for reducing the level of serum LPO
during
low-dose aspirin therapy.
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KEYWORD
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